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Research Shows That Key Ingredients In
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CRYODERM constricts blood vessels when they are over-dilated |
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When your muscles or joints are inflamed, such as after trauma, exertion, or in arthritis, the blood vessels become leaky and let plasma, white blood cells, and cytokines-the so-called "inflammatory soup" out into the surrounding tissue. The tissue becomes red, warm, swollen, and painful. CRYODERM'S® proprietary formulation counteracts the vasodilatory effects of the inflammatory mediators making blood vessels contract. This reduces swelling, redness, inflammation, eliminates pain, discomfort and restores the tissue homeostasis. |
Cryoderm dilates blood vessels when they are in spasm |
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When your muscles are in spasm, the blood vessels are constricted, reducing the blood flow to the area and depriving the tissue of the vital oxygen. In this scenario CRYODERM'S® proprietary formulation causes relaxation of blood vessels and a reduction in sympathetic nerve-mediated contraction. CRYODERM® helps restore the natural balance by dilating the blood vessels, thus improving microcirculation, tissue oxygen supply, removing the toxic by-products of metabolism, resolving interstitial acidosis and speeding up tissue healing. |
Summary
CRYODERM® aids in regulating blood flow depending on the tissue state, restoring natural homeostasis.
What they found:
A transient receptor potential channel that was previously believed to be found only in a subpopulation of sensory neurons, was recently identified in blood vessels. Isometric contraction studies on endothelium-denuded relaxed vessels found small contractions on application of CRYODERM'S® Key Ingredients. However, these ingredients caused relaxation of vessels precontracted with KCl (60 mM) or the α-adrenoceptor agonist phenylephrine (2 µM) and a reduction in sympathetic nerve-mediated contraction. Thus, these key CRYODERM® ingredients play multiple functional roles, likely to be in a tissue- and activation state-dependent manner, producing opposite effects, causing vasoconstriction or vasodilatation, depending on previous vasomotor tone.
References:
Am J Physiol Heart Circ Physiol. 2009 June; 296(6): H1868–H1877.
Christopher D. Johnson, Donal Melanaphy, Andrew Purse, Susan A. Stokesberry, Paula Dickson, and Alexander V. Zholos. Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone. Am J Physiol Heart Circ Physiol. 2009 June; 296(6): H1868–H1877. Cardiovascular Biomedical Research Centre, School of Medicine, Dentistry and Biomedical Sciences, Medical Biology Centre, Queen's University, Belfast, United Kingdom.
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